A proposed marketing strategy for GO2HK.COM

Within these few years, the Internet becomes popular in the world. There are many well-known websites, such as the eBay, Amazon and Yahoo, etc.. In foreign countries, Web auction is very famous for the Internet users in foreign countries, while it is a new kind of electronic business in Hong Kong. The trend of web auction has penetrated into Hong Kong in this few years, but it is still at a growth stage of the industry life cycle. Web auction seems to be a new type of business in electronic commerce, thus it can attract the people to participate it in future. The potential market for web auction is quite large. In Hong Kong, there are four major companies that work on the business of web auction. They are the (1) Red-dots, (2) Go2hk, (3) Yahoo and (4) Clubciti. Whereas, go2hk is the smallest company in terms of company size, it is the second in terms of the number of registered users. The industry is growing rapidly and facing a keen competition. Therefore, the company needs to have good marketing mix strategies to establish its brand name. This project aims to purpose an appropriate marketing strategy of GO2HK.COM, which can allow the company to match the consumer needs with marketing strategy. Interviews are conducted and questionnaire surveys are initiated to look into the most preferable strategy for GO2HK. Before doing the questionnaire survey, we have interviewed the company, in order to identify the current marketing mix first. After that, questionnaire surveys are used to access the information about the procedure of non-users, sellers and bidders. Based on the findings, a proposed marketing strategy is recommended for go2hk. To conclude, security is the most critical aspect that both users and non-users are highly concerned

Effects of physical activity on functional health of older adults: a systematic review

Reviews on the relationships between functional health and physical activity of general older adults have been well documented in literature. However, specific age range of older adults, in particular, older adults of 75 years or above, is currently under-examined. A systematic review was conducted to investigate the effects of physical activity on functional health older adults aged 75 years or above. The reviewed articles cover a variety range of functional health outcomes, including balance, muscle conditioning, joint range of motion, quadriceps strength, reaction time, gait speed, health-related quality of life, back and knee pain, muscle mass, and walking ability. In general, interventions of the reviewed articles had favourable effects on function health of older adults. While physical activity has been identified as an important determinant of functional health, the ways to engage in and accumulate sufficient daily physical activity warrant investigation. It is also important to explore interventions which enhance daily, self-driven physical activity of elderly, as normally supervised physical activity bears higher costs

Hsa-miRNA-765 as a key mediator for inhibiting growth, migration and invasion in fulvestrant-treated prostate cancer

Fulvestrant (ICI-182,780) has recently been shown to effectively suppress prostate cancer cell growth in vitro and in vivo. But it is unclear whether microRNAs play a role in regulating oncogene expression in fulvestrant-treated prostate cancer. Here, this study reports hsa-miR-765 as the first fulvestrant-driven, ERβ-regulated miRNA exhibiting significant tumor suppressor activities like fulvestrant, against prostate cancer cell growth via blockage of cell-cycle progression at the G2/M transition, and cell migration and invasion possibly via reduction of filopodia/intense stress-fiber formation. Fulvestrant was shown to upregulate hsa-miR-765 expression through recruitment of ERβ to the 5′-regulatory-region of hsa-miR-765. HMGA1, an oncogenic protein in prostate cancer, was identified as a downstream target of hsa-miR-765 and fulvestrant in cell-based experiments and a clinical study. Both the antiestrogen and the hsa-miR-765 mimic suppressed HMGA1 protein expression. In a neo-adjuvant study, levels of hsa-miR-765 were increased and HMGA1 expression was almost completely lost in prostate cancer specimens from patients treated with a single dose (250 mg) of fulvestrant 28 days before prostatectomy. These findings reveal a novel fulvestrant signaling cascade involving ERβ-mediated transcriptional upregulation of hsa-miR-765 that suppresses HMGA1 protein expression as part of the mechanism underlying the tumor suppressor action of fulvestrant in prostate cancer. © 2014 Leung et al